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[目的]观察脑髓康与脑心通胶囊联合西药治疗卒中后抑郁疗效。[方法]使用随机平行对照方法,将125例住院患者按病志号抽签简单随机分两组。对照组60例文拉法辛,第一周75mg/次,1次/d,第二周增加到150mg/次,第3周加到225mg/次,第3周若加量不耐受则第4周再加到150mg/次,维持剂量继续治疗。治疗组65例(1)急性期—脑髓康方;(2)脑血管病恢复期及后遗症期—脑心通胶囊;(3)度洛西汀,初始剂量30mg/d,3~7d内增加到60mg/d;(4)睡眠障碍酌情给予苯二氮卓。连续治疗4周为1疗程。观测临床症状、汉密尔顿抑郁量表、视觉模拟评分、不良反应。治疗1疗程,判定疗效。[结果]治疗组痊愈18例,显效25例,有效29例,无效3例,总有效率95.38%;对照组痊愈15例,显效20例,有效15例,无效15例,总有效率83.33%;治疗组疗效优于对照组(P<0.01)。汉密尔顿抑郁量表、视觉模拟评分改善治疗组优于对照组(P<0.01)。[结论]脑髓康与脑心通胶囊联合西药治疗卒中后抑郁,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Nao Kikang and Naoxintong capsules combined with western medicine on post-stroke depression. [Methods] Using randomized parallel control method, 125 inpatients were randomized to two randomized groups according to the patient’s lot number. Control group, 60 cases of venlafaxine, the first week of 75mg / time, 1 / d, the second week increased to 150mg / times, the first 3 weeks to 225mg / times, the first 3 weeks if the amount of intolerance is the fourth Week and then added to 150mg / time, continue to maintain the dose treatment. (3) duloxetine, the initial dose of 30mg / d, increased within 3 ~ 7d. (3) Duloxetine, the initial dose of 30mg / d, increased within 3 ~ 7d To 60mg / d; (4) sleep disorders as appropriate to give benzodiazepine. Continuous treatment for 4 weeks for a course of treatment. Clinical symptoms were observed, Hamilton Depression Scale, visual analogue scale, adverse reactions. Treatment of a course of treatment to determine the efficacy. [Results] The treatment group cured in 18 cases, markedly effective in 25 cases, effective in 29 cases, ineffective in 3 cases, the total effective rate was 95.38%; control group cured 15 cases, markedly effective in 20 cases, effective in 15 cases, ineffective in 15 cases, the total effective rate was 83.33% The treatment group was better than the control group (P <0.01). The Hamilton Depression Scale and Visual Analogue Scale improved the treatment group better than the control group (P <0.01). [Conclusion] Nao Kikang capsule combined with Naoxintong in the treatment of post-stroke depression has satisfactory curative effect and no serious adverse reactions, which deserves promotion.