妊娠高血压综合征（妊高征）是与血管痉挛、多器官系统病理性血管损伤有关的产科常见病[1]，至今病因和发病机制不清。血管性假血友病因子（VonWillbrandFacfor，VWF）为血管内皮细胞损伤的重要标记物，我们测定了正常晚期妊娠及妊高征患者血浆VWF水平，并对其胎盘螺旋小动脉进 Pregnancy-induced hypertension (PIH) is a common obstetric disease associated with vasospasm and multiple organ system pathological vascular injury [1], so far the etiology and pathogenesis are unclear. Von Willebrand Factor (VWF) is an important marker of vascular endothelial cell injury. We measured the plasma levels of VWF in patients with normal late pregnancy and pregnancy induced hypertension (PIH)