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为探讨低水平铅损伤学习记忆功能的作用机理，采用NADPH—黄递酶组织化学方法和3H—瓜氨酸生成生物检测技术，观察了新生大鼠在400mg／L醋酸铅染毒40天后对脑组织内一氧化氮合酶表达及活性的影响。结果显示大脑皮质一氧化氮合酶阳性神经无数量明显减少（P＜0．05），在海马区脑组织内一氧化氮合酶活性降低54．4％。结论：低水平铅暴露后可抑制大鼠脑组织内一氧化氮合酶的表达及活性。
In order to investigate the mechanism of learning and memory function induced by low levels of lead, NADPH-diaphorase histochemistry and 3H-citrulline bioassay were used to observe the effects of lead on brain tissue of neonatal rats exposed to 400 mg / L lead acetate Expression and activity of nitric oxide synthase in The results showed that there was a significant decrease in the number of positive neurons of NOS in the cerebral cortex (P <0.05), and the activity of nitric oxide synthase in the hippocampus decreased 54.4%. Conclusion: Exposure to low levels of lead can inhibit the expression and activity of nitric oxide synthase in rat brain.