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雷尼替丁是一种H_2受体拮抗剂,能有效地抑制胃酸分泌,用于消化性溃疡的治疗。临床多应用雷尼替丁胶囊口服,也有应用注射剂的。为探讨雷尼替丁新剂型应用的可能性,我们对盐酸雷尼替丁和盐酸雷尼替丁缓释胶囊的LD_(50)进行了测定。现报告如下。 1 材料与方法:①动物;昆明种小鼠,由本学院动物室提供,体重18g—22g,雌雄兼用,随机分组。②药物;盐酸雷尼替丁,上海第六制药厂生产,批号;910507,以注射用水配制成所需浓度的溶液供用。盐酸雷尼替丁缓释胶囊,本学院药学系药
Ranitidine is a H 2 receptor antagonist, can effectively inhibit gastric acid secretion, for the treatment of peptic ulcer. Clinical application of ranitidine capsules orally, but also the application of injection. In order to explore the possibility of the new formulation of ranitidine, LD_ (50) of ranitidine hydrochloride and ranitidine hydrochloride sustained release capsules was determined. The report is as follows. 1 Materials and Methods: ① animals; Kunming mice, provided by the College Animal Room, weighing 18g-22g, both male and female, randomized. ② drugs; ranitidine hydrochloride, Shanghai No. 6 Pharmaceutical Factory production, lot number; 910507, formulated with water for injection at the desired concentration of solution for use. Ranitidine hydrochloride sustained-release capsules, the College of Pharmacy drugs