蛋白激酶C家族的新成员蛋白激酶Cδ的激活,可导致若干型细胞的凋亡。尽管基于蛋白激酶Cδ激活的分子基础仍不明了,所知的调控表达机制的信息仍十分有限。该项研究显示,在前列腺肿瘤细胞中蛋白激酶Cδ在转录水平上受雄激素的调节。培养基中缺失类固醇可导致雄激素敏感性前列腺癌 Activation of protein kinase Cδ, a new member of the protein kinase C family, leads to the apoptosis of several types of cells. Although the molecular basis based on the activation of protein kinase Cδ remains unclear, the information known to regulate the expression machinery is still limited. This study shows that protein kinase Cδ is upregulated by androgens at the transcriptional level in prostate tumor cells. Deletion of steroids in the medium can lead to androgen-sensitive prostate cancer