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AIM:Recent clinical epidemiological studies havedemonstrated the preventive effect of non-steroidal anti-inflammatory drugs(NSAIDs)against colorectal cancer.The underlying mechanism might be the inhibition of rate-limiting enzyme cyclooxygenase-2(COX-2)in metabolismof arachidonic acid.The role of COX-2 in carcinogenesisof colorectal cancer and its relationship with tumorbiological characteristics and patients’ prognosis stillremain unclear.This study was to investigate the role ofCOX-2 expression in carcinogenesis of colorectal cancerand its relationship with tumor biological characteristicsand patients’ prognosis.METHODS:A total of 139 colorectal cancers and 19adenomas surgically treated in School of Oncology,PekingUniversity,from January 1993 to September 2001 wereretrospectively studied.COX-2 expression was detected withtissue microarray(TMA)and immunohistochemistry(IHC)procedure.The association between COX-2 expression andclinicopathological features and its influence on patients’prognosis were studied.RESULTS:COX-2 expression was strong in colorectal cancer,moderate in adenoma and weak in normal mucosa,whichdemonstrated statistically significant difference(x~2=46.997,P<0.001).COX-2 expression had no association withclinicopathological features such as gross type,differentiation,invasion depth,vessel emboli and TNMstaging.Cox proportional hazards modeling analysis and Logrank test revealed no prognostic role of COX-2 expressionin colorectal cancer patients.CONCLUSION:COX-2 may play an important role in theearly stage of carcinogenesis,and its expression in colorectalcancer is not associated with clinicopathological features andpatients’ prognosis.
AIM: Recent clinical epidemiological studies have demonstrated the preventive effect of non-steroidal anti-inflammatory drugs (NSAIDs) against colorectal cancer. The underlying mechanism might be the inhibition of rate-limiting enzyme cyclooxygenase-2 (COX-2) in metabolism of arachidonic acid. The role of COX-2 in carcinogenesis of colorectal cancer and its relationship with tumorbiological characteristics and patients ’prognosis stillremain unclear. This study was to investigate the role of COX-2 expression in carcinogenesis of colorectal cancerand its relationship with tumor biological characteristics and patients’ prognosis. METHODS : A total of 139 colorectal cancers and 19adenomas surgically treated in School of Oncology, Peking University, from January 1993 to September 2001 wereretrospectively studied. COX-2 expression was detected with tissue microarray (TMA) and immunohistochemistry (IHC) procedure. The association between COX- 2 expression andclinicopathological features and its influence on patients’p The expression of COX-2 expression was strongly in colorectal cancer, moderate in adenoma and weak in normal mucosa, which demonstrated statistically significant difference (x ~ 2 = 46.997, P <0.001) such as gross type, differentiation, invasion depth, vessel emboli and TNMstaging. Cox proportional hazards modeling and Logrank test revealed no prognostic role of COX-2 expressionin colorectal cancer patients. CONCLUSION: COX-2 may play an important role in the stage carcinogenesis, and its expression in colorectalcancer is not associated with clinicopathological features andpatients’ prognosis.