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目的对非小细胞肺癌(NSCLC)患者实施开胸肺叶切除与全胸腔镜肺叶切除治疗的临床应用效果进行观察与分析。方法随机选择本院2012年9月~2016年9月收治的28例NSCLC患者作为实验组(行全胸腔镜肺叶切除术),另随机选择本院2008年9月~2012年8月本院收治的28例NSCLC患者作为常规组(行开胸肺叶切除术)。比较两组患者治疗后的心肺功能指标、各项临床指标以及并发症发生情况。结果治疗后,实验组患者一氧化碳弥散量(DLCO)为(65.35±6.74)%、心率(HR)为(81.20±14.35)次/min、最大自主通气量(MVV)为(72.51±1.03)%,均分别优于常规组的(71.54±4.32)%、(98.36±10.58)次/min、(64.46±0.25)%,差异均具有统计学意义(P<0.05)。两组患者第1秒用力呼气容积(FEV1)、淋巴结清扫数比较,差异无统计学意义(P>0.05)。实验组患者手术时间为(163.58±11.54)min、引流时间为(4.23±0.42)d均短于常规组的(142.56±10.42)min、(6.47±0.63)d,实验组患者手术失血量为(98.69±26.75)ml少于常规组的(157.45±39.52)ml,实验组患者疼痛评分为(5.12±1.74)分低于对照组的(8.84±1.21)分,实验组并发症发生率为7.14%低于常规组的28.57%,差异均具有统计学意义(P<0.05)。结论在NSCLC治疗中采用全胸腔镜肺叶切除术进行治疗的应用效果优于开胸肺叶切除术,值得推广。
Objective To observe and analyze the clinical effect of open lobectomy and thoracoscopic lobectomy in patients with non-small cell lung cancer (NSCLC). Methods A total of 28 NSCLC patients admitted to our hospital from September 2012 to September 2016 were selected as the experimental group (underwent thoracoscopic lobectomy) and randomly selected in our hospital from September 2008 to August 2012 in our hospital Of 28 patients with NSCLC as a routine group (open lobectomy). The two groups of patients after treatment of cardiopulmonary function indicators, the clinical indicators and complications. Results After treatment, the patients with experimental group had a significantly higher level of DLCO (65.35 ± 6.74)%, HR (81.20 ± 14.35) / min and MVV (72.51 ± 1.03)%, (71.54 ± 4.32)%, (98.36 ± 10.58) /min, (64.46 ± 0.25)%, respectively. The difference was statistically significant (P <0.05). Two groups of patients with forced expiratory volume 1 second (FEV1), the number of lymph node dissection, the difference was not statistically significant (P> 0.05). The operation time of the experimental group was (163.58 ± 11.54) min and the drainage time was (4.23 ± 0.42) d respectively, which was shorter than that of the conventional group (142.56 ± 10.42 min, 6.47 ± 0.63) d. The blood loss of the experimental group was 98.69 ± 26.75) ml less than that of the conventional group (157.45 ± 39.52) ml, the pain score of the experimental group was (5.12 ± 1.74) lower than that of the control group (8.84 ± 1.21), the incidence of complications in the experimental group was 7.14% Lower than 28.57% of the conventional group, the difference was statistically significant (P <0.05). Conclusion The application of thoracoscopic lobectomy in the treatment of NSCLC is superior to that of thoracotomy and lobectomy, which is worthy of promotion.