老年人极易患癌症,但关于年龄对化疗剂毒性影响方面的资料却未见报道.本文就是探讨是否年龄为5-氟尿嘧啶(5-FU)毒性的独立危险因素.方法收集用5-FU为主治疗晚期结肠直肠癌患者前瞻性、随机化、多中心试验的毒性资料加以分析.对中毒的每个器官系统进行分级.各个器官的毒性用卡方分析加以比较.对年龄(小于70岁对70岁及70岁以上者),性别、治疗方式,完成状况及治疗期限作为预示严重中毒的模式参数,进行逻辑回归,对331名患者的毒性进行了分析. The elderly are very susceptible to cancer, but there is no information on the effect of age on the toxicity of chemotherapeutic agents. This article is to investigate whether the age is an independent risk factor for 5-fluorouracil (5-FU) toxicity. Methods for the collection of 5-FU for Analysis of toxicities of prospective, randomized, multicenter trials in patients with advanced colorectal cancer was analyzed. Each organ system of intoxication was graded. Toxicity of each organ was compared using chi-square analysis. For ages (less than 70 years old 70-year-old and 70-year-old), gender, treatment methods, completion status and duration of treatment as model parameters predicting severe poisoning, a logistic regression, the toxicity of 331 patients were analyzed.