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采用酶联双抗体夹心法,对36例哮喘患者和54例正常献血者(对照组)进行了外周血单个核细胞诱生白细介素2(IL-2)水平的检测。结果;哮喘组外周血单个核细胞诱生的IL-2活性[吸光度(A)值]为0.2015±0.0225,血浆可溶白细胞介素2(sIL-2)水平为167.5±52.4kU/L,均高于对照组[前者A值为0.1881±0.0300,后者为(114.2±48.6)kU/L(P<0.05,P<0.01)]。提示:外源性哮喘患者发病中存在着T淋巴细胞的活化,导致IL-2诱生水平和血浆sIL-2R水平的增高,二者在哮喘发病机制中起着一定的作用。
Enzyme-linked immunosorbent assay (ELISA) was used to detect interleukin-2 (IL-2) levels in peripheral blood mononuclear cells in 36 asthmatic patients and 54 normal donors (control group). Results: IL-2 activity [absorbance (A) value] of peripheral blood mononuclear cells in asthma group was 0.2015 ± 0.0225, and plasma soluble interleukin 2 (sIL-2) level was 167.5 ± 52.4kU / L, both Higher than the control group [the former A value was 0.1881 ± 0.0300, the latter was 114.2 ± 48.6 kU / L (P <0.05, P <0.01)]. TIP: The activation of T lymphocytes in patients with exogenous asthma leads to the induction of IL-2 and the increase of plasma sIL-2R, both of which play a role in the pathogenesis of asthma.