青霉素G为临床常用的抗生素,其肾毒性较小,为肾衰患者常用的抗感染药物。青霉素G在体内以原形经肾脏排除,在肾衰患者体内由于排泄受阻而使药物的消除半衰期延长。腹膜透析可增加药物的清除速率。我们对5名肾衰伴腹透患者,1名肾衰患者静滴青霉素G后的清除及药代动力学进行了研究,现报告如下:材料与方法受试者6人,均为慢性肾炎,严重肾功能不全(尿毒症)患者。青霉素G钠溶于5％葡萄糖注射液中静滴,于测定当日或隔日凌晨采血进行血液生化分析,测定血清肌 Penicillin G is a commonly used clinical antibiotics, its nephrotoxicity is small, commonly used anti-infective drugs for patients with renal failure. Penicillin G in the body by the prototype ruled out by the kidney in patients with renal failure due to excretion blocked the elimination of drugs to extend the half-life. Peritoneal dialysis increases the rate of drug clearance. We have five renal failure with peritoneal dialysis patients, a renal failure patients after intravenous penicillin G clearance and pharmacokinetics are reported as follows: Materials and Methods Subjects 6 were chronic nephritis, Severe renal insufficiency (uremia) patients. Penicillin G dissolved in 5% glucose intravenous infusion of blood on the day of the test or early morning after another blood biochemical analysis of blood, muscle was measured