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为了认识生殖周期中子宫巨噬细胞的分布，用Ｆ４／８０单克隆抗体，对小鼠子宫巨噬细胞进行了免疫组织化学标记。结果显示，间情期子宫内膜中有大量巨噬细胞，动情前期数量略有减少，但子宫系膜三角区出现较多巨噬细胞。动情期子宫内膜中有少量巨噬细胞，动情后期显著减少。在动情期和动情后期，子宫系膜三角区中均有较多巨噬细胞，妊娠１ｄ的子宫内膜中巨噬细胞数量很少，妊娠７ｄ的子宫蜕膜中则消失。妊娠１４ｄ子宫的壁蜕膜组织中有少量巨噬细胞，在子宫肌间偶见，基蜕膜与子宫腺区中未见巨噬细胞。妊娠１８ｄ子宫中，壁蜕膜中巨噬细胞明显增多，子宫腺区也有少量，同时子宫系膜基部可见许多，但基蜕膜中未见巨噬细胞。产后１ｄ子宫中，巨噬细胞在内膜中数量极多，子宫肌间可见成簇分布。产后３ｄ子宫内膜结构基本恢复正常，其内仍有许多巨噬细胞。实验结果提示：子宫巨噬细胞在妊娠早期数量减少可能与胚泡着床有关；分娩前后子宫巨噬细胞的增多可能与产后子宫的修复有关
To understand the distribution of uterine macrophages in the reproductive cycle, mouse uterine macrophages were immunohistochemically labeled with F4 / 80 monoclonal antibody. The results showed that there are a large number of macrophages in the estrous endometrium, the number of estrus decreased slightly, but there were more macrophages in the mesangial triangle. Estrus endometrium in a small amount of macrophages, significantly reduced the late estrus. In the estrus and late estrus, there are more macrophages in the mesenteric trigone region, the number of macrophages in the endometrium on day 1 of pregnancy is very small, and the uterine decidua on day 7 of pregnancy disappears. Pregnancy 14d uterine wall decidual tissue in a small amount of macrophages, occasionally seen in the uterine muscle, basal deciduas and uterine glands in the absence of macrophages. 18d pregnant uterus, wall decidual macrophages increased significantly, a small amount of uterine glandular area, while the basal mesentery can be seen many, but no decidual basal macrophages. 1d postpartum uterus, a large number of macrophages in the intima, fascicles can be seen in the distribution between the uterus. Postpartum 3d endometrial structure returned to normal, there are still many macrophages. The experimental results suggest that the decrease of uterine macrophages in early gestation may be related to blastocyst implantation. The increase of uterine macrophages before and after labor may be related to the repair of postpartum uterus