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艾氏腹水癌细胞在cUMP(浓度为10~(-6)-10~(12M)/10~6细胞)作用下,生长受到抑制,随cUMP浓度降低,抑制作用减小。在10~(-7)M/10~6细胞cUMP作用下,胞内cAMP水平几乎没有变化,而cGMP水平升高38.3％(P<0.005)。浓度为10~(-6)-10~(-12)McUMP对胞内cAMP-PDE活性几乎没有影响,而抑制cGMP-PDE的活性,抑制作用随cUMP浓度降低而减小,这可能是胞内cGMP水平增高的原因。cUMP可能与细胞的cAMP PK结合,释放催化亚单位,细胞生长的抑制可由此发生。
Ehrlich ascites cancer cells in cUMP (concentration of 10 ~ (-6) -10 ~ (12M) / 10 ~ 6 cells), the growth was inhibited, with cUMP concentration decreased, inhibition decreased. Intracellular cAMP levels showed almost no change in 10 -7 M / 10 6 cells, whereas cGMP levels increased 38.3% (P <0.005). The effect of cGMP-PDE was inhibited by 10 ~ (-6) -10 ~ (-12) McUMP with little effect on the intracellular cAMP-PDE activity and the inhibition decreased with the decrease of cUMP concentration, which may be intracellular The reason for increased cGMP levels. cUMP may bind to cellular cAMP PK, releasing catalytic subunits. Inhibition of cell growth may thus occur.