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为了解静脉丙种球蛋白 (IVIG)治疗儿童严重急性呼吸综合征 (SARS)临床疗效 ,分析10例SARS患儿的症状及用IVIG200～400mg/(kg·d)前后体温、外周血白细胞、胸部X线改变及其转归。10例患儿中 ,男女各5例 ,主要表现为发热 (100% )和咳嗽 (80% ) ,外周血白细胞总数在IVIG治疗前后分别为 (2.72±1.92)×109/L及(5.81±1.52)×109/L(P<0.01) ,用IVIG后第1、2、3、4d ,体温下降至正常分别为1、6、9、10例;患儿胸片均表现为斑片状局灶性非对称性浸润性阴影 ,肺部病灶变化快 ,肺部阴影消退在用IVIG后明显吸收时间为 (10.0±3.5)d。给予隔离、通风、充分休息、加强营养、低流量吸氧、预防细菌感染综合治疗基础上 ,用IVIG ,全部病例临床治愈出院。提示IVIG对广州地区儿童SARS的高热、外周血白细胞降低及肺部病灶的吸收有一定疗效。
To understand the clinical efficacy of intravenous gamma globulin (IVIG) in the treatment of children with severe acute respiratory syndrome (SARS), the symptoms of 10 children with SARS were analyzed and the changes of body temperature, peripheral blood leukocytes, chest X Line changes and their return. There were 5 males and 5 females in each of the 10 cases. The main manifestations were fever (100%) and cough (80%). The total number of peripheral leukocytes was (2.72 ± 1.92) × 109 / L before and after IVIG treatment (5.81 ± 1.52 ) × 109 / L (P <0.01). The body temperature decreased to normal at 1, 2, 3 and 4 days after IVIG respectively in 1, 6, 9 and 10 cases Asymmetric invasive infiltration of the shadow, rapid changes in lung lesions, lung shadow regression significantly after IVIG absorption time (10.0 ± 3.5) d. Given isolation, ventilation, adequate rest, strengthen nutrition, low flow oxygen, prevention of bacterial infections based on comprehensive treatment, with IVIG, all cases of clinical cure and discharge. It is suggested that IVIG may have some effects on SARS fever, peripheral blood leukopenia and pulmonary lesions in children in Guangzhou.