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为研究不同位置的氨基糖对阿霉素类的抗肿瘤活性的构效关系,以2-氨基葡萄糖为原料合成了4个2-氨基-2-脱氧-D-葡萄糖衍生物;以D-葡萄糖为原料通过8步反应合成了3-脱氧-3-邻苯二甲酰亚胺基-D-阿洛糖衍生物。
In order to study the structure-activity relationship of the aminosugar on the antitumor activity of adriamycin, four 2-amino-2-deoxy-D-glucose derivatives were synthesized from 2-glucosamine. D-glucose The 3-deoxy-3-phthalimido-D-allose derivatives were synthesized by 8 steps.