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目的探讨先兆子痫患者凝血-纤维活性与血小板指标变化的关化及其临床意义。方法检测112例先兆子痫患者(先兆子痫组又分轻、重度先兆子痫组)、54例妊娠妇女(妊娠组)以及37例非妊娠妇女(非妊娠组)的凝血-纤维活性和血小板的相关指标,采用统计学方法进行比较。结果重度先兆子痫凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)及抗凝血酶Ⅲ(AT-Ⅲ)与其他三组比较差异均有统计学意义(P<0.05或0.01),凝血酶时间(TT)与轻度先兆子痫组和妊娠组相比差有统计学意义(P<0.05或0.01);先兆子痫血小板计数(PLT)较妊娠组及非妊娠组明显减少(P<0.01),而血小板分布宽度(PDW)、血小板体积(MPV)增高(P<0.01)。重度先兆子痫PLT、PDW与轻度相比,差异均有统计学意义(均P<0.05),重度先兆子痫组产科并发症的发生率显著增加。结论先兆子痫患者血液的高凝状态和血小板指标远远超过妊娠妇女及非妊娠妇女,子痫前期患者的凝血-纤维活性平衡失调,失调的严重程度与患者病情程度直接相关。
Objective To investigate the relationship between coagulation - fibrosis activity and platelet index in preeclampsia and its clinical significance. Methods Coagulation-fibrinolytic activity and platelet counts were measured in 112 patients with preeclampsia (pre-eclampsia group with mild and severe preeclampsia), 54 pregnant women (pregnancy group) and 37 non-pregnant women (non-pregnant women) The relevant indicators, using statistical methods to compare. Results The differences of PT, APTT, FIB and AT-Ⅲ in severe preeclampsia between the three groups were statistically significant (P <0.05 or 0.01). Thrombin time (TT) was significantly lower than that of mild preeclampsia group and pregnancy group (P <0.05 or 0.01). PLT of preeclampsia was significantly higher than that of pregnancy (P <0.01), but PDW and MPV increased significantly (P <0.01). Severe preeclampsia PLT, PDW compared with mild, the difference was statistically significant (both P <0.05), severe preeclampsia group obstetric complication rate was significantly increased. Conclusions The blood hypercoagulability and platelet index in patients with preeclampsia far outweigh the differences in the coagulation-fibroeactivity balance between preeclampsia and nonpregnant women. The severity of the disorder is directly related to the severity of the disease.