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目的:评价大黄联合血液净化治疗鱼胆中毒并发多脏器功能障碍综合征的临床疗效和安全性。方法:采用回顾性分析方法,37例血液净化治疗鱼胆中毒患者为对照组,32例大黄联合血液净化治疗鱼胆中毒患者为治疗组,比较2组受损脏器恢复情况、治愈率、病死率及药品不良反应等。结果:2组患者治疗后21d血尿素氮、血肌酐、N-乙酰β-D氨基葡萄糖苷酶、尿量恢复率、ALT、AST、总胆红素、直接胆红素,少尿期恢复时间、消化系统损伤恢复倒数,凝血酶原时间、血小板(第7天),痊愈时间、治愈率等指标比较,差异均有统计学意义(P<0.05)。结论:大黄联合血液净化治疗鱼胆中毒并发多脏器功能障碍综合征疗效优于单纯血液净化治疗。
Objective: To evaluate the clinical efficacy and safety of rhubarb combined with blood purification in the treatment of fish gallbladder poisoning complicated by multiple organ dysfunction syndrome. Methods: A retrospective analysis of 37 cases of blood purification treatment of fish gallbladder poisoning as a control group, 32 cases of rhubarb combined with blood purification treatment of fish gall intoxication patients for the treatment group, compared the recovery of two groups of damaged organs, the cure rate, death Rate and adverse drug reactions. Results: The blood urea nitrogen, serum creatinine, N-acetyl-D-glucosaminidase, urine output, ALT, AST, total bilirubin, direct bilirubin, oliguria recovery time , The reciprocal of digestive system injury recovery, prothrombin time, platelet (the seventh day), the recovery time, cure rate and other indicators, the differences were statistically significant (P <0.05). Conclusion: Rhubarb combined with blood purification treatment of fish gallbladder poisoning complicated by multiple organ dysfunction syndrome is better than pure blood purification treatment.