脑缺血能引起神经细胞释放氨基酸,但其释放和脑缺血的部位、缺血时间有关,增加的氨基酸通过各种机制使细胞内Ca~(2+)增高,从而造成神经元的损害。文章就脑缺血后脑氨基酸释放的选择性、氨基酸增高及引起细胞功能损害机制与脑皮层离子变化作一综述。 Cerebral ischemia can cause nerve cells to release amino acids, but its release is related to the site of cerebral ischemia and ischemic time. The increased amino acids increase intracellular Ca ~ (2+) through various mechanisms, resulting in neuronal damage. This article reviews the brain amino acid release after brain ischemia, the increase of amino acids and the mechanism of cell dysfunction and cortical ion changes.