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抗HIV靶向治疗是利用特异性的运载工具,将可杀伤HIV-1感染靶细胞的生物活性弹头选择性地运送到感染靶细胞部位,通过与靶细胞相结合后内化,杀灭体内残存病毒颗粒和潜伏感染细胞,并修复机体免疫系统,恢复机体正常免疫功能。将靶向治疗作为艾滋病(AIDS)治疗的辅助和补充手段,正成为AIDS一种新型的治疗方法。本文就抗HIV靶向治疗的运载工具及生物活性弹头的研究进展作一综述。
Anti-HIV targeted therapy is the use of specific delivery vehicles that will kill HIV-1 infected target cells of biological activity of warhead selectively transported to infected target cell sites, by combining with the target cells after internalization to kill the body remnants Virus particles and latent infection cells, and repair the body’s immune system, restore the body’s normal immune function. Targeted therapy as an adjunct to and complementary to AIDS treatment is becoming a new treatment for AIDS. This article reviews the research progress of delivery vehicles and bioactive warheads against HIV targeted therapy.