肿瘤抗原肽的寻找已成为当前肿瘤研究领域的一大热点。它包括癌基因蛋白抗原肽、致癌病毒基因抗原肽、肿瘤特异性抗原肽和组织特异性分化抗原肽等。这些抗原肽在与MHC类分子结合后 ,提呈到细胞表面被相应T细胞受体识别 ,从而激活细胞毒性T淋巴细胞的活性 ,使机体产生特异性抗肿瘤免疫应答。因而它们在肿瘤免疫接种和免疫治疗等方面有着广阔的应用前景。 The search for tumor antigen peptides has become a hot topic in the field of tumor research. It includes oncogene protein antigen peptides, oncogene viral gene antigen peptides, tumor-specific antigen peptides, and tissue-specific differentiation antigen peptides. After binding to MHC molecules, these antigen peptides are presented to the cell surface and recognized by the corresponding T cell receptors, thereby activating the activity of cytotoxic T lymphocytes and enabling the body to generate specific anti-tumor immune responses. Therefore, they have broad application prospects in tumor immunity and immunotherapy.