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目的：凯时（前列腺素E1）在手足外科中用于断指再植术后预防血管危象的临床效果。方法我科86例112指断指再植病例，随机分为两组，对照组给予常规治疗，实验组在常规治疗的基础上使用凯时。对两组患者术后血管危象发生率、凝血功能及血液流变学进行统计分析，比较两组疗效。结果与对照组相比，实验组血管危象发生率低，血液粘度降低，两组凝血功能无明显差别。讨论凯时用于断指再植手术，能够预防血栓形成，降低血管危象的发生率，有较好的临床应用价值。“,”Object:to explore the effect of alprostadil injection used for the prevention of vascular crisis after replantation of severed fingers. Method:86 patients with 112 replanted fingers were randomly devided into 2 groups. The control group was given conventional treatment and the patients in treatment group were given alprostadil injection besides theconventional treatment. The incidence of vascular crisis, the coagulation function and blood rheology were analyze to evaluate the curative effect. Result:Compared with the control group, the treatment group was with low incidence of vascular crisis and reduce blood viscosity. The coagulation function was no significant difference between the 2 groups. Conclusion:It suggests thar in the finger replantation surgery, the alprostadil was of great clinical value for its prevention of thrombosis and reduction of the vascular crisis.