Objective:To evaluate antiplasmodial and analgesic activities of ethanolic leaf extract/ fractions of Panicum maximum.Methods:The crude leaf extract(47-190 mg/kg) and fractions (chlor of orm,ethyl acqeous and methanol;96 mg/kg) of Panicum maximum were investigated for antiplasmodial activity against chloroquine sensitive Plasmodium berghei infections in mice and for analgesic activity against chemical and heat-induced pains.The antiplasmodial activity during early and established infections as well as prophylactic were investigated.Artesunate at 5 mg/kg and pyrimethamine at 1.2 mg/kg were used as positive controls.Analgesic activity of the crude extract/fractions was also evaluated against acetic acid,formalin and heat-induced pains.Results:The extract and its fractions dose-dependently reduced parasitaemia induced by chloroquine sensitive Plasmodium berghei infection in prophylactic,suppressive and curative models in mice.These reductions were statistically significant(P<0.001).They also improved the mean survival time from 13 to 28 days compared with control(P<0.001).The activities of extract/ fractions were incomparable to that of the standard drugs(Artesunate and pyrimethamine).On chemically and thermally-induced pains.the extract inhibited acetic acid and formalin-induced inflammation as well as hot plate-induced pain in mice.These inhibitions were statistically significant(P<0.001) and in a dose-dependent fashion.Condusions:Panicum maximum leaf extract has antiplasmodial and analgesic activities which may in part be mediated through the chemical constituents of the plant. Objective: To evaluate antiplasmodial and analgesic activities of ethanolic leaf extract / fractions of Panicum maximum. Methods: The crude leaf extract (47-190 mg / kg) and fractions (chlor of orm, ethyl acqeous and methanol; 96 mg / kg) of Panicum maximum were investigated for antiplasmodial activity against chloroquine sensitive Plasmodium berghei infections in mice and for analgesic activity against chemical and heat-induced pains.The antiplasmodial activity during early and established infections as well as prophylactic were investigated. Artesunate at 5 mg / kg and pyrimethamine at 1.2 mg / kg were used as positive controls. Analgesic activity of the crude extract / fractions was also evaluated against acetic acid, formalin and heat-induced pains.Results: The extract and its fractions dose-dependently reduced parasitaemia induced by chloroquine sensitive Plasmodium berghei infection in prophylactic, suppressive and curative models in mice. These reductions were statistically significant (P <0.001) .yay lso improved the mean survival time from 13 to 28 days compared with control (P <0.001). The activities of extract / fractions were incomparable to that of the standard drugs (Artesunate and pyrimethamine) .On chemically and thermally-induced pains.the extract inhibited acetic acid and formalin-induced inflammation as well as hot plate-induced pain in mice. The inhibitions were significantly significant (P <0.001) and in a dose-dependent fashion. Conusions: Panicum maximum leaf extract has antiplasmodial and analgesic activities which may in part be mediated through the chemical constituents of the plant.