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目的研究荷瘤宿主免疫无能与其树突状细胞（ＤＣ）免疫功能间相关性。方法以健康成人（ｎ＝１０）作为对照，检测１０名临床确诊的肝癌患者外周血ＤＣ表面ＨＬＡ－ＤＲ及Ｂ７表达水平及其免疫诱导能力。结果发现肝癌患者ＤＣ表面ＨＬＡ－ＤＲ及Ｂ７表达水平（６．７±１．６及６．１±１．１）明显低于对照组（１０．７±１．４及９．６±１．２，Ｐ＜０．０５）；其ＤＣ体外诱导Ｔ细胞增殖的能力（６２００±９０ｃｐｍ）明显低于对照组（３１００±１２０ｃｐｍ，Ｐ＜０．０５）；以抗ＨＬＡ－ＤＲ单抗及抗Ｂ７单抗封闭正常人ＤＣ后，其诱导Ｔ细胞增殖能力亦明显低于对照组。结论肝癌患者ＤＣ表面ＨＬＡ－ＤＲ及Ｂ７表达低下致ＤＣ的免疫功能低下，而ＤＣ的免疫功能低下则可能是肝癌（或许包括其他肿瘤）逃避宿主免疫监视的重要原因
Objective To study the correlation between tumor-immune host immune dysfunction and dendritic cell (DC) immune function. Methods Healthy adults (n=10) were used as controls to detect the expression of HLA-DR and B7 on the surface of peripheral blood of 10 clinically diagnosed patients with hepatocellular carcinoma and their immune induction ability. The results showed that the levels of HLA-DR and B7 on the surface of DCs in patients with hepatocellular carcinoma (6.7±1.6 and 6.1±1.1) were significantly lower than those in the control group (10.7±1.4 and 9.6±1. 2. P<0.05); The ability of DCs to induce T cell proliferation in vitro (6200±90 cpm) was significantly lower than that of the control group (3100±120 cpm, P<0.05); with anti-HLA-DR monoclonal antibody and anti-B7 After blocking the normal human DCs, mAbs also showed significantly lower T cell proliferation than the control group. Conclusion The low level of HLA-DR and B7 on DC surface of patients with hepatocellular carcinoma results in low immune function of DC, and the low immune function of DC may be an important reason for liver cancer (including other tumors) to evade host immune surveillance.