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目的探讨克罗恩病(Crohns disease,CD)与血清胱抑素C(cystatin C,CysC)的相关性。方法 CD男性患者28例(CD组),同期体检健康男性22例(对照组),比较2组年龄、有无吸烟史、体质量指数、血肌酐、克罗恩病活动指数(Crohns disease activity index,CDAI)评分及血清CysC等参数差异,分析CD患者病情变化及其与CysC的相关性。结果 CD组CysC水平((1.04±0.18)mg/L)高于对照组((0.80±0.13)mg/L)(P=0.00);CD缓解期和活动期CysC水平比较差异无统计学意义(P>0.05);CD组与对照组血肌酐水平比较差异无统计学意义(P>0.05);单因素相关分析显示年龄、CDAI分值及体质量指数在CysC正常组与CysC升高组差异有统计学意义;logistic多元回归分析结果显示CDAI分值是CysC升高的独立危险因素(OR=1.02,95%CI:1.01~1.03,P=0.00)。结论多数男性CD患者CysC水平升高,CDAI评分是CysC升高的独立危险因素。
Objective To investigate the correlation between Crohn’s disease (CD) and serum cystatin C (CysC). Methods 28 males (CD group) and 22 healthy males (control group) were enrolled in this study. The age, smoking history, body mass index, serum creatinine, Crohn’s disease index activity index (CDAI) score and serum CysC and other parameters were analyzed. The changes of CD patients and their correlations with CysC were analyzed. Results The level of CysC in CD group was significantly higher than that in control group ((1.04 ± 0.18) mg / L vs (0.80 ± 0.13) mg / L, P = 0.00) (P> 0.05). There was no significant difference in serum creatinine between CD group and control group (P> 0.05). The correlation between age, CDAI score and body mass index in CysC normal group and CysC elevated group was significant Statistical analysis showed that CDAI score was an independent risk factor for CysC increase (OR = 1.02, 95% CI: 1.01-1.03, P = 0.00). Conclusions CysC levels are elevated in most male patients with CD, CDAI score is an independent risk factor for CysC increase.