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通过体外实验观察到Ｒｈｏｄｅｓｉａ温石棉，新康温石棉和ＵＩＣＣ温石棉、青石棉、铁石棉具有诱发８－羟脱氧鸟苷（８－ＯＨ－ｄＧ）产生而损伤小牛胸腺ＤＮＡ的作用，加入Ｈ＿２Ｏ＿２和（或）ＦｅＳＯ＿４可明显增强石棉纤维致８－ＯＨ－ｄＧ产生的作用。以ＵＩＣＣ青石棉纤维的作用最强，ＵＩＣＣ铁石棉纤维次之，Ｒｈｏｄｅｓｉａ温石棉、新康温石棉和ＵＩＣＣ温石棉纤维最弱。由此可见石棉纤维致８－ＯＨ－ｄＧ产生的作用与石棉种类和羟自由基的参与有关。作者认为８－ＯＨ－ｄＧ的产生可影响ＤＮＡ中腺嘌呤与胸腺嘧啶、鸟嘌呤与胞嘧啶的碱基配对，诱发ＤＮＡ点突变，与肿瘤的发生有关。
In vitro experiments showed that Rhodesia chrysotile, New Kangweng asbestos and UICC chrysotile, crocidolite and amosite had the effect of inducing 8-OH-dG to damage calf thymus DNA, adding H 2 O 2 And (or) FeSO 4 can significantly enhance the role of asbestos fibers caused by 8-OH-dG. UICC asbestos fibers play the strongest role, followed by UICC asbestos fibers, Rhodesia asbestos, asbestos and UICC asbestos fibers weakest. This shows that the role of asbestos fibers caused by 8-OH-dG and asbestos types and the involvement of hydroxyl radicals. The authors believe that the generation of 8-OH-dG can affect DNA in the base pair of adenine and thymine, guanine and cytosine, induced DNA point mutation, and tumorigenesis.