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目的 探讨结直肠癌患者手术前后血清中可溶性P -selectin和IL - 8含量的变化及其临床意义。方法 用ELISA法和RIA法分别测定结直肠癌患者手术前 ,手术后及复发病人血清sP -selectin和IL - 8的含量 ,并与对照组进行比较。结果 结直肠癌患者血清sP -selectin和IL - 8的含量明显高于正常人 (P <0 .0 1) ,术后 3个月下降至接近正常人水平 ,而复发患者则再次升高 (P <0 .0 1)。结论 血清sP -selectin和IL - 8的含量与结直肠癌的发生 ,发展及预后密切相关。
Objective To investigate the changes of serum soluble P-selectin and IL-8 in patients with colorectal cancer before and after operation and their clinical significance. Methods The levels of sP - selectin and IL - 8 in serum of patients with colorectal cancer before operation, after operation and after relapse were determined by ELISA and RIA respectively and compared with those of the control group. Results The levels of sP - selectin and IL - 8 in patients with colorectal cancer were significantly higher than those in normal controls (P <0.01). The levels of serum sP - selectin and IL - 8 in patients with colorectal cancer were lower than those in normal controls at 3 months, <0 .0 1). Conclusion The levels of sP-selectin and IL-8 in serum are closely related to the occurrence, development and prognosis of colorectal cancer.