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In order to obtain a ligand with higheraffinity and longer retention time than G-018for benzodiazepine (BZ) receptor imaging, aseries of derivatives of gastrodigenin weresynthesized. By competitive receptor bindingassays, the IC_(60) values of various derivativesinhibiiting ~(125)I-G018 binding were in therange of 3.4×10~(-8)-7.9×10~(-6) mol/L. Alpha-
In order to obtain a ligand with higheraffinity and longer retention time than G-018for benzodiazepine (BZ) receptor imaging, a series of derivatives of gastrodigenin weresynthesized. By competitive receptor bindingassays, the IC 60 values of various derivatives inhibit ~ 125 I- G018 binding were in therange of 3.4 × 10 ~ (-8) -7.9 × 10 ~ (-6) mol / L. Alpha-