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目的研究血清同型半胱氨酸(HCY)、C反应蛋白(CRP)和纤维蛋白原(FIB)及血管壁内膜-中层厚度(IMT)与动脉硬化性脑梗死发生的相关性。方法将2010年6月～2011年6月在我院住院治疗的、诊断为脑梗死的患者62例,符合OCSP分型中完全前循环梗死(TACI)8例、部分前循环梗死(PACI)41例,后循环梗死(POCI)13例,年龄50～75岁,健康对照组选自我院体检科体检者30例,男14例,女16例,年龄50～75岁,分别在患者发病后及健康对照组入选后一周内监测血清HCY、CRP、FIB及颈部IMT水平。结果脑梗死患者中,IMT及血清HCY、CRP三项均高于正常对照组,差异有统计学意义(P<0.05)。结论脑梗死患者血清HCY、CRP、FIB及颈部IMT水平较对照组均明显增高,针对其进行积极干预,对于改善脑梗死患者病情及预后具有重要价值。
Objective To investigate the relationship between serum homocysteine (HCY), C-reactive protein (CRP) and fibrinogen (FIB) and intima-media thickness (IMT) in vascular wall and arteriosclerosis infarction. Methods Totally 62 patients diagnosed as cerebral infarction who were hospitalized in our hospital from June 2010 to June 2011 were eligible for the OCSP classification, including 8 cases of complete anterior circulation infarction (TACI), partial anterior circulation infarction (PACI) 41 Cases, 13 cases of posterior circulation infarction (POCI), aged 50 to 75 years old, healthy control group was selected from the physical examination in our hospital 30 cases, 14 males and 16 females, aged 50 to 75 years old, respectively, after the onset and The healthy control group were monitored serum HCY, CRP, FIB and neck IMT within a week after enrollment. Results Among the patients with cerebral infarction, IMT, serum HCY and CRP levels were significantly higher than those in the normal control group (P <0.05). Conclusions The levels of serum HCY, CRP, FIB and neck IMT in patients with cerebral infarction were significantly higher than those in the control group, and their active intervention was of great value in improving the disease and prognosis of patients with cerebral infarction.