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患儿,男,14岁,患急性支气管炎。某乡村医院给卡那霉素1g,加50%葡萄糖50ml,静脉推注,药物推至2/3时,患儿突然憋气,呼吸困难、面色苍白、四肢厥冷,继之唇、面、指(趾)端发绀、两眼凝视。立即终止卡那霉素推注,用肾上腺素1mg 肌注;可拉明,洛贝林各1支肌注。又加地塞米松10mg 静脉滴注。继后,又施人工呼吸,胸外心脏按摩,针刺人中、十宣穴等。终因抢救无效而死亡。追问过去史,有链霉素皮试阳性史。笔者认为:①卡那霉素一般不应作为呼吸系统感染的首选药物。②卡那霉素不应静脉推注。③大剂量用卡那霉素时,可引起呼吸抑制。④链霉素与卡那霉素有交叉过敏性。患者属于卡那霉素中毒及过敏性休克致死。
Children, male, 14 years old, suffering from acute bronchitis. A village hospital kanamycin 1g, plus 50% glucose 50ml, intravenous injection, the drug pushed to 2/3, the child suddenly suffocated, dyspnea, pale, extremities Jueleng, followed by the lips, noodles, fingers (Toe) side cyanosis, his eyes staring. Immediately stop kanamycin bolus, intramuscular injection of 1mg adrenaline; Lamine, Lobelin 1 intramuscular injection. Plus dexamethasone 10mg intravenous infusion. Followed by, they also apply artificial respiration, chest cardiac massage, acupuncture in the people, such as ten Xuan point. The end of the rescue died. Asked the past history, a history of streptomycin skin test positive. The author thinks: ① kanamycin generally should not be used as the drug of choice for respiratory infections. ② kanamycin should not be intravenous injection. ③ high-dose kanamycin, can cause respiratory depression. ④ streptomycin and kanamycin cross-allergy. Patients are kanamycin poisoning and anaphylactic shock lethal.