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目的:观察25μg米索前列醇用于足月妊娠促宫颈成熟及计划分娩的效果及安全性。方法:选择2011年1～10月有计划分娩指征的住院足月妊娠初产妇,观察组62例使用米索前列醇25μg阴道后穹隆促宫颈成熟计划分娩,间隔24 h重复给药,最大剂量75μg;抽取60例同等条件、无催产素计划分娩禁忌证、自愿接受催产素计划分娩者作为对照组,常规使用催产素计划分娩。结果:观察组足月妊娠促宫颈成熟的总有效率为83.9%,计划分娩成功率77.4%,显著高于对照组的65.0%和56.7%(P<0.05),剖宫产率亦低于对照组(P<0.05),但新生儿出生体重及新生儿窒息率与对照组比较差异无统计学意义(P>0.05)。结论:小剂量米索前列醇阴道用药用于足月妊娠能有效促宫颈成熟,计划分娩成功率高,是一种方便、安全、经济、有效的计划分娩方法。
Objective: To observe the effect and safety of 25 μg misoprostol for full-term pregnancy promoting cervical ripening and planned delivery. Methods: From January to October of 2011, the first term of hospitalized term pregnant women who had planned delivery was enrolled. In the observation group, 62 cases were treated with misoprostol 25μg intravaginal vaginal fornix and cervical ripening plan and delivered with repeated interval of 24 hours. The maximum dose 75μg; extracted 60 cases of the same conditions, no contraception of obstetrics and childbirth contraception, voluntary acceptance of oxytocin plan delivery as a control group, routine use of oxytocin plan delivery. Results: The total effective rate of full-term pregnancy promoting cervical ripening in observation group was 83.9%, the success rate of scheduled delivery was 77.4%, significantly higher than that of control group (65.0% and 56.7%, P <0.05), and the rate of cesarean section was lower than that of control (P <0.05). However, there was no significant difference in neonatal birth weight and neonatal asphyxia between the two groups (P> 0.05). Conclusion: Small doses of misoprostol vaginal medication for full-term pregnancy can effectively promote cervical ripening, planned delivery rate is high, is a convenient, safe, economical and effective planned delivery method.