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目的通过观察急性心肌梗死 ( AMI)患者组织纤维化血清学指标变化 ,探讨其与 AMI面积大小的关系及其反映心肌纤维化的临床价值。方法测定 AMI患者再通组 42例 ,未通组 2 2例及正常对照组 37例血清中 型前胶原 ( PC )、 型胶原 ( · C)和层粘连蛋白 ( laminin,L N)含量 ;采用 Michelle等公式计算出梗死面积 ,并将各组参数间和梗死面积作相关分析。结果 AMI患者未通组血清PC 、 ·C、LN含量较其他两组增高显著 ,并与梗死面积呈正相关 ;但其他两组的参数之间及其与梗死面积的关系无统计学意义。结论血清 PC 、 ·C、LN均可作为 AMI患者心肌组织纤维化的血清学指标 ,并可间接反映梗死面积大小。
Objective To observe the changes of fibrosis serological markers in patients with acute myocardial infarction (AMI) and to explore its relationship with the size of AMI and the clinical value of myocardial fibrosis. Methods The serum level of procollagen (PC), collagen (C) and laminin (LN) in 42 cases of AMI patients, 22 cases of AMI patients and 37 cases of normal control group were measured by Michelle et al Formula calculated infarct size, and each group of parameters and infarct size for correlation analysis. Results The levels of PC, C and LN in patients with AMI were significantly higher than those in other two groups and positively correlated with the infarct size. However, there was no significant relationship between the parameters of the other two groups and the infarct size. Conclusion Serum PC, · C, LN can be used as serum markers of myocardial tissue fibrosis in patients with AMI, and indirectly reflect the infarct size.