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目的评价序贯应用前列腺素E_1类药物治疗X综合征的疗效。方法 150例确诊为X综合征的患者,随机分为常规治疗组及前列腺素E_1类药物治疗组,各75例,观察两组患者的心绞痛发作情况、活动平板试验参数、冠状动脉造影校正的TIMI帧数(CTFC)指标。结果 (1)经1年治疗,两组患者心绞痛发作频度、发作持续时间均较治疗前有所下降(P<0.05),且前列腺素E_1类药物治疗组下降效果优于常规治疗组(P<0.05)。前列腺素E_1类药物治疗组治疗总有效率94.67%高于常规治疗组84.00%(P<0.05)。(2)经1年治疗,两组患者平板运动试验的总运动时间、到达运动终点时间及至心绞痛发作时间、至ST段下移1 mm时间较治疗前均有所增加(P<0.05),且前列腺素E_1类药物治疗组的增加效果优于常规治疗组(P<0.05)。(3)经1年治疗后,两组CTFC均明显下降(P<0.05),且前列腺素E_1类药物治疗组的下降效果优于常规治疗组(P<0.05)。结论前列腺素E_1类药物对于X综合征的治疗是安全、有效的。
Objective To evaluate the efficacy of sequential application of prostaglandin E_1 in the treatment of syndrome X. Methods A total of 150 patients diagnosed with syndrome X were randomly divided into routine treatment group and prostaglandin E_1 group, 75 cases in each group. The angina pectoris, activity plate test parameters, coronary angiography corrected TIMI Frame count (CTFC) indicator. Results (1) After one year of treatment, the frequency of angina attacks and the duration of seizure decreased in both groups (P <0.05), and the decreasing effect of prostaglandin E_1 group was better than that of conventional treatment group (P <0.05). The total effective rate of the prostaglandin E_1 group was 94.67% higher than that of the conventional treatment group (84.00%, P <0.05). (2) After 1-year treatment, the total exercise time, the time to reach the end of exercise and the onset time of angina in the treadmill exercise test in both groups were significantly increased (P <0.05) The effect of prostaglandin E_1 group was better than that of routine treatment group (P <0.05). (3) After one year of treatment, the CTFC of both groups decreased significantly (P <0.05), and the effect of prostaglandin E_1 group was better than that of conventional treatment group (P <0.05). Conclusion Prostaglandin E_1 is safe and effective for the treatment of syndrome X.