ｐ16和ｐ15基因已被公认为肿瘤抑制基因 ,通过参与细胞周期负调控调节机体代谢 ,维持自身稳定 ,控制着肿瘤的发生 ,作用较Ｒｂ和ｐ5 3更直接 ,特异性更强 ,在多种肿瘤的发生机制研究及利用抑癌基因的治疗中引起关注。现就其在白血病中的研究进展综述如下 :1　ｐ16和ｐ15基因的 The p16 and p15 genes have been recognized as tumor suppressor genes. They are involved in the negative regulation of the cell cycle to regulate body metabolism, maintain their own stability, and control the occurrence of tumors. The effects are more direct and more specific than those of Rb and p53. The mechanism of occurrence and the use of tumor suppressor gene therapy have attracted attention. The research progress in leukemia is summarized as follows: 1 The p16 and p15 genes