论文部分内容阅读
难治性肾病综合征是肾小球疾病中常见的临床病症,治疗比较棘手。传统的糖皮质激素联合中药治疗,疗效较差。为了提高难治性肾病综合征的疗效,探讨病理类型与疗效的关系,我们于1995年3月至1998年6月对62例难治性肾病综合征,采用大剂量环磷酰胺(CTX)冲击治疗,取得了显著疗效。1 资料和方法1．1 临床资料全部病例均为我院住院患者,男34例,女28例;年龄16~63岁,平均(31.2±5.6)岁。病程最短3个月,最长10年,平均30个月。全部病例均符合下列诊断标准中的任何一项:①激素抵抗型:经正规激素治疗8周无效者;②激素依赖型:经正规激素治疗后达到缓解,但激素减量或停药后复发;③常复发型:1年复发3次或半年内复发2次。
Refractory nephrotic syndrome is a common clinical disease in glomerular diseases, the treatment is more difficult. Traditional glucocorticoid combined with traditional Chinese medicine treatment, poor efficacy. In order to improve the curative effect of refractory nephrotic syndrome and to explore the relationship between the pathological type and curative effect, we treated 62 refractory nephrotic syndromes from March 1995 to June 1998 with a high dose of cyclophosphamide (CTX) Treatment, and achieved a significant effect. 1 Materials and Methods 1.1 Clinical data All cases were hospitalized in our hospital, 34 males and 28 females; aged 16 to 63 years, mean (31.2 ± 5.6) years. The shortest duration of 3 months, up to 10 years, an average of 30 months. All cases were in line with any of the following diagnostic criteria: ① hormone-resistant type: normal hormone therapy for 8 weeks ineffective; ② hormone-dependent: remission after treatment with formal hormones, but hormones reduced or relapsed after drug withdrawal; ③ often recurring type: 1 year recurrence 3 or recurrence within 2 months 2 times.