远端溃疡性结肠炎病人应用类固醇激素(如倍他米松)灌肠治疗后,往往会产生柯兴氏综合征和丘脑下垂体肾上腺(HPA)轴的抑制。本文报道应用二丙酸培氯米松(Beclomethasone dipropionate BDP)灌肠治疗取得与倍他米松相同的效果,但不产生HPA轴的抑制和柯兴氏综合征。方法和结果:对健康志愿者HPA轴的影响:6名健康志愿者(男4例,女2例,平均20～40岁),应用随机双盲交叉研究。先取静脉血测定血浆皮质素浓度作对 Treatment of patients with distal ulcerative colitis with corticosteroids such as betamethasone often results in inhibition of Cushing’s syndrome and hypothalamic-pituitary-adrenal (HPA) axis. This article reports that the same effect as betamethasone was obtained with enema of Beclomethasone dipropionate BDP but not HPA axis inhibition and Cushing’s syndrome. Methods and Results: Effect on HPA Axis in Healthy Volunteers: Six healthy volunteers (4 males and 2 females, average 20 to 40 years) were randomized double-blind crossover study. Venous blood taken first plasma cortisol concentration for the right