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为观察重组 (酵母 )乙型肝炎 (乙肝 )疫苗在不同人群中的免疫效果 ,于 1997～ 2 0 0 2年随机抽取 1～ 5 9岁人群 ,进行乙肝病毒 (HBV)感染史和乙肝疫苗接种史调查。根据调查情况 ,将调查对象分为易感人群和非易感人群 ,对易感人群和非易感人群分别接种重组 (酵母 )乙肝疫苗 ,以观察重组 (酵母 )乙肝疫苗对不同人群的免疫效果。结果表明 :易感人群接种重组 (酵母 )乙肝疫苗 ,能显著提高人群抗乙肝病毒表面抗体 (抗 HBs)阳性率 ,降低乙肝病毒表面抗原 (HBsAg)、乙肝病毒核心抗体 (抗 HBc)阳性率。免疫起始年龄越小 ,免疫效果越好。 5年以内 ,抗 HBs阳性率维持在 77 6 %以上。不同HBV感染情况的非易感人群 ,接种重组 (酵母 )乙肝疫苗的免疫效果不同 ,抗 HBc单项阳性效果较好 ,接种后抗 HBs上升到 77 5 4 %。说明重组 (酵母 )乙肝疫苗用于易感人群和抗 HBc单项阳性的非易感人群免疫效果良好。
To observe the immune effect of recombinant (yeast) Hepatitis B (HBV) vaccine in different populations, a random sample of people aged 1-59 years from 1997 to 2002 was enrolled in this study. The history of hepatitis B virus (HBV) infection and hepatitis B vaccination History survey. According to the survey, the subjects were divided into susceptible and non-susceptible groups, and the susceptible and non-susceptible groups were inoculated recombinant (yeast) hepatitis B vaccine to observe the immune effect of recombinant (yeast) hepatitis B vaccine on different populations . The results showed that vaccination of recombinant (yeast) hepatitis B vaccine in susceptible population could significantly increase the positive rate of anti-HBs and reduce the positive rate of HBsAg and HBc in the population. The lower the initial immunization age, the better the immune response. Within 5 years, the positive rate of anti-HBs maintained above 77 6%. In non-susceptible population with different HBV infection status, vaccination with recombinant (yeast) hepatitis B vaccine had different immunogenic effects. The anti-HBc single positive effect was better, and the anti-HBs level increased to 77.54% after inoculation. This indicates that the recombinant (yeast) hepatitis B vaccine has a good immune effect in susceptible and anti-HBc non-susceptible non-susceptible populations.