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目的判断老年人冠心病是否与脉压水平及CRP水平密切相关,并探讨非显性炎症在老年人冠心病发病过程中所起的作用及CRP对于冠心病发生的预测价值。方法应用酶多克隆抗体夹心法对CRP进行测定分析,并在不同脉压水平下对于冠心病的发病率进行比较。结果随着PP的增加,冠心病的发生率有增加趋势(P<0.05),CRP>3 mg/L时冠心病的发病率对于在<3 mg/L时也有显著性的升高(P<0.01)。结论老年人的脉压水平与冠心病发生密切相关,CRP对于老年人冠心病的产生及发展有评估价值。
Objective To determine whether coronary heart disease (CHD) is closely related to pulse pressure and CRP levels in the elderly and to explore the role of non-apparent inflammation in the pathogenesis of CHD and the predictive value of CRP for CHD. Methods The polyclonal antibody sandwich enzyme-linked immunosorbent assay (ELISA) was used to determine and analyze CRP. The incidence of coronary heart disease was compared at different pulse pressure levels. Results The incidence of coronary heart disease increased with the increase of PP (P <0.05). The incidence of coronary heart disease was also significantly increased at <3 mg / L when CRP> 3 mg / L (P < 0.01). Conclusion The pulse pressure of the elderly is closely related to the occurrence of coronary heart disease. CRP is of value in the diagnosis and treatment of coronary heart disease in the elderly.