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目的探讨肝门部胆管癌的临床及病证特征并探讨各种手术方式和预后的关系。方法回顾分析2001—2007年间282例肝门部胆管癌,根据手术方式不同将其分为根治性切除组(A)、姑息切除组(B)、胆道引流组(C)和剖腹探查组(D),比较各组之间生存时间和预后。结果 A、B、C、D组的中位生存时间分别为29、14、7和3个月,组间生存时间有显著性差异(P<0.05)。12例生存时间超过5年以上的患者均为根治性切除组。结论手术方式是肝门部胆管癌重要的预后因素,根治性切除是患者获得治愈和长期生存的重要措施。
Objective To investigate the clinical and pathological characteristics of hilar cholangiocarcinoma and to explore the relationship between various surgical modalities and prognosis. Methods 282 cases of hilar cholangiocarcinoma between 2001-2007 were retrospectively analyzed. According to the different surgical methods, they were divided into radical resection group (A), palliative resection group (B), biliary drainage group (C) and laparotomy group ), To compare the survival time and prognosis between the groups. Results The median survival time in groups A, B, C and D was 29, 14, 7 and 3 months, respectively, with significant differences in survival time between groups (P <0.05). All 12 patients survived for more than 5 years were treated by radical resection. Conclusions The surgical approach is an important prognostic factor for hilar cholangiocarcinoma. Radical resection is an important measure for patients to obtain cure and long-term survival.