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目的分析重型β地中海贫血(thalassemia major,TM)患者生长发育状况及其影响因素。方法对365例TM患者测量其身高、体质量并计算其Z值,同时检测输血前血红蛋白(hemoglobin,Hb)、血清铁蛋白(serum ferritin,SF)、甲状腺功能、促性腺激素及性激素浓度,进行相关分析。结果 365例TM患者中,37.5%发育迟缓,7.4%低体质量。发育迟缓发生率随年龄增加而增加,高量输血及低铁负荷患者发育相对较好。38例患者检测甲状腺功能,其中6例患者存在甲状腺功能减退;27例检测性激素水平,15例患者存在性发育障碍。结论 TM患者常伴有生长发育迟缓,主要与治疗不规范有关。TM患者应监测身高、体质量及激素水平。
Objective To analyze the growth and development status and its influencing factors in patients with thalassemia major (TM). Methods The height and body mass of 365 patients with TM were measured and their Z values were calculated. Meanwhile, hemoglobin (Hb), serum ferritin (SF), thyroid function, gonadotropin and sex hormone levels before transfusion were measured. related analysis. Results Of 365 patients with TM, 37.5% were stunted and 7.4% were low-grade. The incidence of stunting increases with age, and high blood transfusion and low iron load patients develop relatively well. Thyroid function was detected in 38 patients, of which 6 had hypothyroidism, 27 had sex hormone levels, and 15 had developmental disorders. Conclusion TM patients often accompanied by growth retardation, mainly related to non-standard treatment. TM patients should monitor height, body mass and hormone levels.