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了解苯那普利(benazapril)的降低慢性肾小球肾炎原蛋白的作用。方法:对慢性肾炎病人64例进行多中心自身对照观察。结果:经苯那普利治疗12周后,大量蛋白尿组(30例)尿蛋白下降47.0%,小量蛋白尿组(34例)尿蛋白下降 47.5%,平均起效时间分别为( 5.1±3. 2)周(大量蛋白尿组)和( 2. 7±2. 1)周(小量蛋白尿组),同时,其中14例肾病综合征患者的低白蛋白血症也有明显改善。结论:苯那普利可部分地降低慢性肾小球肾炎患者的尿蛋白。
To understand the effect of benazapril on reducing chronic glomerulonephritis protein. Methods: 64 cases of chronic glomerulonephritis patients were multicenter self-control observation. Results: After 12 weeks of benazepril treatment, urinary protein decreased by 47.0% in large proteinuria group (30 cases) and decreased by 47.5% (34 cases) in small proteinuria group (averaged 5.1 ± 3.2 weeks (mass proteinuria group) and (2.7 ± 2.1) weeks (small proteinuria group), while 14 patients with nephrotic syndrome hypoalbuminemia also significantly improved. Conclusion: Benazepril partially reduces urinary protein in patients with chronic glomerulonephritis.