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目的 探讨根治性切除术联合肝动脉置管化疗对高位胆管癌预后的影响.方法 选择我院收治的76例高位胆管癌患者进行研究为研究对象,进行根治性切除术.根据术后化疗方案不同随机分为观察组和对照组各38例,观察组患者接受肝动脉置管化疗,对照组接受常规静脉化疗,比较两组患者的预后情况、肝肾功能、血清肿瘤标志物含量.结果 预后情况:观察组患者的客观有效率(RR)、疾病控制率(DCR)明显高于对照组,无肿瘤进展生存时间(PFS)、总体生存时间(OS)明显长于对照组(t/x2=4266~11403,P<005);肝肾功能:观察组谷丙转氨酶(ALT)、谷草转氨酶(AST)、白蛋白(ALB)均明显低于对照组(t=3686~20736,P<005);肿瘤标志物:观察组患者血清糖类抗原(CA19-9)、糖类抗原(CA12G5)、基质金属蛋白酶-7(MMPG7)含量明显低于对照组(t=17868~26802,P<005).结论 根治性切除术联合肝动脉置管化疗有助于改善预后情况,延长生存时间,减轻肝肾功能损伤,降低血清肿瘤标志物含量.
Objective To investigate the effect of radical resection combined with hepatic arterial catheterization on the prognosis of high cholangiocarcinoma.Methods 76 cases of cholangiocarcinoma admitted to our hospital were selected as study subjects for radical resection.According to the different postoperative chemotherapy regimens Randomly divided into observation group and control group 38 cases, observation group received hepatic arterial catheter chemotherapy, the control group received routine intravenous chemotherapy, the prognosis of the two groups were compared, liver and kidney function, serum tumor markers.Results Prognosis (RR) and disease control rate (DCR) in observation group were significantly higher than those in control group. There was no significant difference between the two groups in the progression-free survival time (PFS) and overall survival time (OS) 11403, P <005). Liver and kidney function: ALT, AST and ALB in the observation group were significantly lower than those in the control group (t = 3686-20736, P <005) The levels of serum carbohydrate antigen (CA19-9), carbohydrate antigen (CA12G5), and matrix metalloproteinase-7 (MMPG7) in the observation group were significantly lower than those in the control group (t = 17868-26802, P < Radical resection combined with hepatic artery catheterization chemotherapy can help improve the prognosis, Extend survival time, reduce liver and kidney dysfunction, reduce serum tumor marker content.