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目的探讨Napsin A对卵巢上皮性癌的诊断价值与关系。方法采用SP免疫组织化学方法检测50例卵巢透明细胞癌、50例卵巢浆液性癌、50例卵巢内膜样腺癌患者的癌组织中Napsin A的表达。结果卵巢透明细胞癌组Napsin A表达阳性率94.0%,显著高于卵巢浆液性癌组4.0%和卵巢内膜样腺癌组8.0%,差异均有统计学意义(P<0.05);卵巢浆液性癌组Napsin A表达阳性率与卵巢内膜样腺癌组差异无统计学意义(P>0.05)。结论 Napsin A可以作为诊断卵巢透明细胞癌的特异性肿瘤标记物,是判断卵巢透明细胞癌及鉴别诊断其他类型卵巢上皮性癌的重要指标。
Objective To investigate the diagnostic value and relationship of Napsin A in epithelial ovarian cancer. Methods SP immunohistochemistry was used to detect the expression of Napsin A in 50 cases of ovarian clear cell carcinoma, 50 cases of ovarian serous carcinoma and 50 cases of ovarian endometrial adenocarcinoma. Results The positive rate of Napsin A expression in ovarian clear cell carcinoma was 94.0%, which was significantly higher than that in ovarian serous carcinoma (4.0%) and ovarian endometrioid adenocarcinoma (8.0%), the differences were statistically significant (P <0.05) The positive rate of Napsin A in cancer group was not significantly different from that in endometrioid adenocarcinoma (P> 0.05). Conclusion Napsin A can be used as a specific tumor marker in the diagnosis of clear cell carcinoma of the ovary and is an important index for judging the clear cell carcinoma of ovary and differentiating other types of epithelial ovarian cancer.