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探讨癌基因在前列腺癌发生发展中意义，应用免疫组化S－P（过氧化物酶—链霉卵白素）法对50例前列腺癌组织中bcl－2、P53和c－erb－B2的表达产物进行检测。结果bcl－2、P53和c－erb－B2的表达率为42％、48％和44％，bcl－2、P53和c－erb－B2的表达与肿瘤的分级、分期皆相关。66％肿瘤有癌基因表达异常，26％的肿瘤同时有多个癌基因表达异常，多个癌基因表达异常与分级、分期相关，bcl－2的表达与P53的表达呈负相关：（γ＝-0．51，P<0．05）。结论：上述癌基因参与了前列腺癌发生发展过程，肿瘤多个基因分析比单个分析更有价值。
To investigate the significance of oncogenes in the development and progression of prostate cancer. Expressions of bcl-2, P53 and c-erb-B2 in 50 cases of prostate cancer tissues were detected by immunohistochemical S-P (peroxidase-streptavidin) The product is tested. Results The expression rates of bcl-2, P53 and c-erb-B2 were 42%, 48% and 44% respectively. The expressions of bcl-2, P53 and c-erb-B2 were correlated with tumor grade and stage. Sixty-six percent of tumors had abnormal expression of oncogenes, 26% of tumors had multiple oncogenes abnormally expressed, and multiple oncogenes were abnormally correlated with grading and staging. The expression of bcl-2 was negatively correlated with the expression of P53 (γ = -0.51, P <0.05). Conclusion: The above oncogenes are involved in the development of prostate cancer. Multiple genetic analysis of tumors is more valuable than single analysis.