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目的:探讨中枢神经系统感染性患儿救治过程中应用醒脑静的疗效及安全性,为临床中枢神经系统感染性患儿的救治提供可靠的参考依据。方法:将2010—2012年间本院收治的中枢神经系统感染患儿178例作为本次研究对象,根据治疗方法不同分为两组,对照组96例患儿给予西医常规治疗,观察组82例患儿在西医治疗的基础上给予醒脑静静脉注射。比较两组患者的疗效。结果:观察组患儿总有效率为93.9%(77/82),对照组患儿总有效率为85.4%(82/96),治疗后总有效率比较,差异有统计学意义(P<0.05)。组内治疗前、后血液LDH和CRP指标进行比较,差异有统计学意义(P<0.05);治疗后组间比较,观察组优于对照组,差异有统计学意义(P<0.05)。治疗后患儿不良反应比较,观察组优于对照组,差异有统计学意义(P<0.05)。结论:醒脑静治疗本病疗效确切,且不良反应较低,安全性较好,值得临床广泛应用。
Objective: To investigate the efficacy and safety of xingnaojing in the treatment of children with central nervous system infection and to provide a reliable reference for the treatment of children with central nervous system infection. Methods: 178 cases of children with central nervous system infection admitted to our hospital during 2010-2012 were divided into two groups according to different treatment methods. 96 children in the control group were given routine western medicine treatment and 82 cases in the observation group Children on the basis of Western medicine given Xingao brain intravenous injection. Compare the efficacy of two groups of patients. Results: The total effective rate was 93.9% (77/82) in the observation group and 85.4% (82/96) in the control group. The total effective rate after the treatment was statistically significant (P <0.05 ). The levels of LDH and CRP in blood before and after treatment in the two groups were statistically significant (P <0.05). After treatment, the observation group was better than the control group (P <0.05). Adverse reactions in children after treatment, the observation group was better than the control group, the difference was statistically significant (P <0.05). Conclusion: Xingnaojing is effective in treating this disease with low adverse reactions and good safety, which is worth widely clinical application.