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目的：探讨不同海拔高度不同居住高原时间健康人脂质代谢状况；方法：对从平原进驻海拔３７００ｍ和５３８０ｍ高原第７天和半年的某部官兵血清胆固醇（Ｃｈ），甘油三酯（ＴＧ），高密度脂蛋白（ＨＤＬ—Ｃ），低密度脂蛋白（ＬＤＬ—Ｃ）及载脂蛋白Ａ—１（ＡｐｏＡ—１），载脂蛋白Ｂ（ＡｐｏＢ）进行检测，并与海拔１４００ｍ健康青年作对照。结果：初入高原Ｃｈ、ＴＧ明显高于平原（Ｐ＜０．０５或Ｐ＜０．０１），且随海拔高度的升高而增高（Ｐ＜０．０１），居住时间的延长而降低（Ｐ＜０．０５或Ｐ＜０．０１）。ＨＤＬ—Ｃ和ＬＤＬ—Ｃ在海拔３７００ｍ居住半年及５３８０ｍ居住第７天和半年均较平原降低显著（Ｐ＜０．０５或Ｐ＜０．０１），ＬＤＬ—Ｃ随居住时间的延长，海拔高度的升高而降低（Ｐ＜０．０１）。ＨＤＬ—Ｃ变化无显著性差异（Ｐ＜０．０５）。ＡｐｏＡ—１在进驻５３８０ｍ第７天和半年明显低于平原（Ｐ＜０．０５或Ｐ＜０．０１），且随居住时间的延长而增高（Ｐ＜０．０５）；ＡｐｏＢ在５３８０ｍ居住半年明显高于第７天及海拔１４００ｍ（Ｐ＜０．０５）。结论：高原地区缺氧引起脂质代谢加强，这可能是机体对维持细胞和组织的能量供给的一种应激性反应。
Objective: To investigate the lipid metabolism status of healthy people at different altitudes at different altitudes; Methods: The serum cholesterol (Ch), triglyceride (TG), creatinine HDL-C, LDL-C, ApoA-1 and ApoB were detected and compared with healthy young people at 1400 m altitude . Results: Ch, TG in the plateau were significantly higher than those in the plain (P <0.05 or P <0.01), and increased with altitude (P <0.01) P <0.05 or P <0.01). HDL-C and LDL-C decreased significantly (P <0.05 or P <0.01) at 7th and 6th months of residence at 3700m and 7th and 6th months respectively. LDL-C increased with the increase of living time and altitude (P <0.01). There was no significant difference in HDL-C (P <0.05). ApoA-1 was obviously lower than plain at 7th day and 6th month after 5380m stationed (P <0.05 or P <0.01), and increased with residence time (P <0.05); ApoB lived at 5380m for 6 months Significantly higher than the first 7 days and 1400m above sea level (P <0.05). CONCLUSIONS: Hypoxia causes increased lipid metabolism in the plateau, which may be a stress response of the body to maintain the energy supply to cells and tissues.