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目的 探讨尿微量蛋白在小儿重症肺炎的肾功能变化。方法 选择重症肺炎小儿 48例 ,轻症肺炎 5 2例 ,正常健康儿童 5 0例 ,分别采用放免法、酶联免疫吸附法测定各组的尿α1 - 微球蛋白 ,尿微量白蛋白 (Alb) ,尿视黄醇结合蛋白 (RBP) ,血尿素氮 (BUN)、肌酐 (Cr) ,进行组间对照分析。结果 重症肺炎组α1 -MG、Alb、RBP明显高于轻症肺炎组 (P <0 .0 1)、轻症肺炎组和健康对照组比较 (P >0 .0 5 ) ,各组间BUN .Cr无显著意义。结论 α1 -MG、Alb、RBP是一个简便、敏感、无创伤、特意性强的指标 ,能反映小儿重症肺炎早期的肾功能损害 ,对指导临床治疗具有重要意义。
Objective To investigate the changes of renal microelements in children with severe pneumonia. Methods 48 cases of severe pneumonia, 52 cases of mild pneumonia and 50 cases of normal healthy children were selected. Urinary α1 - microglobulin and urinary albumin (Alb) were measured by radioimmunoassay and radioimmunoassay. , RBP, BUN and Cr, and compared between two groups. Results The levels of α1-MG, Alb and RBP in severe pneumonia group were significantly higher than those in mild pneumonia group (P <0.01). There was no difference between mild pneumonia group and healthy control group (P> 0.05). Cr no significant meaning. Conclusion α1-MG, Alb, RBP is a simple, sensitive, noninvasive and strong intention indicators that can reflect the early renal damage in children with severe pneumonia, which is of great significance to guide the clinical treatment.