细胞凋亡与细胞增殖的动态平衡是维系机体生长发育、内环境稳定的重要机制。肿瘤不仅是细胞增殖和分化异常的疾病,也是细胞凋亡异常的疾病,肿瘤细胞通过各种机制逃逸凋亡而获得永生性是恶性肿瘤发生、发展的重要机制之一。凋亡抑制蛋白(inhibitors of apopotosis proteins,IAPs)家族是一类新的细胞内源性抗凋亡蛋白,结构上具有同源性,其-NH2端都包含1个或多个特征性BIR结构 The dynamic balance of apoptosis and cell proliferation is an important mechanism to maintain the growth and development of the body and the internal environment. Tumor is not only a disease with abnormal cell proliferation and differentiation, but also a disease with abnormal apoptosis. It is one of the important mechanisms for cancer cells to survive and evolve through escape of apoptosis by various mechanisms. The inhibitors of apopotosis proteins (IAPs) are a new family of endogenous anti-apoptotic proteins that are structurally homologous and contain at their -NH2 terminus one or more characteristic BIR structures