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用口服法进行青霉素脱敏有青霉素类过敏史或皮试直接阳性反应病人,需用青霉素G或青霉素衍生物治疗威胁生命的感染时,可用口服脱敏法来处置青霉素过敏。曾对30例包括细菌性心内膜炎,假单胞菌败血症或肺炎需用羧苄青霉素的病人,以及需用抗青霉素酶的新青Ⅱ治疗的葡萄球菌感染病人,采用了这种脱敏方法。起始口服青霉素G100U或羧苄青霉素60微克,每15分钟加倍剂量。连续观察病人的过敏反应。6小时内给予静脉注射的全治疗量。全部病人脱敏成功。开始治疗后5～48小时内9例发生荨麻疹,用抗组织胺剂治疗。1例在青霉素治疗后3周发生可复性肾炎。
Penicillin desensitization with oral method There is a history of penicillin allergy or skin test direct positive reactions, penicillin G or penicillin derivatives need to be used to treat life-threatening infections, oral desensitization can be used to deal with penicillin allergy. Thirty patients with carbenicillin, including bacterial endocarditis, pseudomonas sepsis or pneumonia, and those infected with staphylococci requiring treatment with penicillin-resistant Neo-½ were employed with this desensitization method. Start oral penicillin G100U or carbenicillin 60 micrograms, every 15 minutes to double the dose. Continuous observation of the patient’s allergic reaction. Intravenous in 6 hours to give the full amount of treatment. All patients desensitization success. Urticaria occurred in 9 patients within 5 to 48 hours after initiation of treatment and was treated with antihistamine. One patient developed refolding nephritis 3 weeks after penicillin treatment.