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目的 探讨新生儿肾上腺皮质囊性变的临床意义。方法 回顾分析本院1990～1996年资料完整的70例尸检新生儿肾上腺组织形态学变化及临床资料。结果 新生儿肾上腺组织结构仍具有胎儿期特征，在29例中出现肾上腺皮质囊性变。胎龄≤36 w者，肾上腺皮质囊性变发生率高于胎龄>36 w者(60% vs 24.57%，χ2=9.95，P<0.005)；围产期窒息者肾上腺皮质囊性变发生率高于非窒息者。组织化学染色显示肾上腺皮质囊性变与永久皮质的脂质含量减少有关(P<0.05)。结论 肾上腺皮质囊性变与围产期缺氧、婴儿成熟度有关，可能为一种应激反应。
Objective To investigate the clinical significance of neonatal adrenocortical cystic degeneration. Methods The morphological changes and clinical data of adrenal tissue in 70 autopsy neonates from 1990 to 1996 in our hospital were retrospectively analyzed. Results Neonatal adrenal tissue structure still has fetal characteristics, in 29 cases of adrenal cortex cystic degeneration. The incidence of adrenocortical cystic degeneration was higher than that of gestational age> 36 w (60% vs 24.57%, χ2 = 9.95, P <0.005) in gestational age ≤36 w. The incidence of adrenocortical cystic degeneration in perinatal asphyxia Higher than non-asphyxiation. Histochemical staining showed cystic degeneration of the adrenal cortex associated with decreased cortical lipid content (P <0.05). Conclusion Adrenocortical cystic degeneration and perinatal hypoxia, infant maturity, may be a stress response.