目的分析多发性骨髓瘤患者Th1、Th2细胞在疾病的不同阶段的水平差异及其临床意义。方法应用流式细胞仪检测了36例多发性骨髓瘤患者IFN-γ和IL-4的水平。结果在初诊和难治性患者中平均Th1/Th2比率较对照组明显升高,在高Th1/Th2比率组血清β2-微球蛋白量较正常Th1/Th两组明显增高。结论高Th1/Th2比率可提示多发性骨髓瘤的不良预后。 Objective To analyze the levels of Th1 and Th2 cells in patients with multiple myeloma at different stages of the disease and their clinical significance. Methods The levels of IFN-γ and IL-4 in 36 patients with multiple myeloma were detected by flow cytometry. Results The average Th1 / Th2 ratio in the newly diagnosed and refractory patients was significantly higher than that in the control group. The level of β2-microglobulin in the high Th1 / Th2 group was significantly higher than that in the normal Th1 / Th group. Conclusion The high Th1 / Th2 ratio may indicate the poor prognosis of multiple myeloma.