胃、十二指肠溃疡是一种古老而又常见的疾病。近20年来西方某些国家其住院率及死亡率有所下降,而我国从50年代到70年代仍有增加趋势,直至十年以前,治疗上进展不大。近年由于对胃分泌生理及胃粘膜细胞保护功能研究的进展,特别是1977年甲氰咪胍广泛应用以来,多种有效新药涌入临床,某些传统药物(如抗酸剂、抗胆硷能剂)也得到新的评价。我省近年在抗溃疡新药研制及临床研究方面, Stomach, duodenal ulcer is an ancient and common disease. In the past two decades, the hospitalization rate and death rate in some western countries have declined. However, there was an increasing trend in our country from the 1950s to the 1970s. Until 10 years ago, there was not much progress in treatment. In recent years, due to the progress of research on the physiology of gastric secretion and the protective function of gastric mucosal cells, especially since the widespread use of cimetidine in 1977, a variety of effective new drugs have been introduced into clinical practice. Some traditional drugs (such as antacids, anticholinergic Agent) also get a new evaluation. In recent years in our province in the development of new anti-ulcer drugs and clinical research,